Project: CRCNS Hippocampus: hc-11

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Description

Recordings from hippocampal area CA1, PRE, during and POST novel spatial learning. [about]

This data set is composed of eight bilateral silicon-probe multi-cellular electrophysiological recordings performed on four male Long-Evans rats. These recordings were performed to assess the effect of novel spatial learning on hippocampal CA1 neural firing and LFP patterns in naïve animals. Each session consisted of a long (~4 hour) PRE rest/sleep epoch home-cage recordings performed in a familiar room, followed by a Novel MAZE running epoch (~45 minutes) in which the animals were transferred to a novel room, and water-rewarded to run on a novel maze. These mazes were either A) a wooden 1.6m linear platform, B) a wooden 1m diameter circular platform or C) a 2m metal linear platform. Animals were rewarded either at both ends of the linear platform, or at a predetermined location on the circular platform. The animal was gently encouraged to run unidirectionally on the circular platform. After the MAZE epochs the animals were transferred back to their home-cage in the familiar room where a long (~4 hour) POST rest/sleep was recorded. All eight sessions were concatenated from the PRE, MAZE, and POST recording epochs. In addition to hippocampal electrophysiological recordings, neck EMG and head-mounted accelerometer signals were recorded, and the animal’s position during MAZE running epochs was tracked via head-mounted LEDs.

Some publications based on all or parts of these data are:

Grosmark, A.D., and Buzsáki, G. (2016). Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences. Science 351, 1440–1443.

Chen, Z., Grosmark, A.D., Penagos, H., and Wilson, M.A. (2016). Uncovering representations of sleep-associated hippocampal ensemble spike activity. Sci. Rep. 6, 32193.



Animals

Animal name

Investigator

Sessions

Animal actions

Achilles
Male, Rat, Long Evans
Wild type
Andres Grosmark 2
Buddy
Male, Rat, Long Evans
Wild type
Andres Grosmark 1
Cicero
Male, Rat, Long Evans
Wild type
Andres Grosmark 3
Gatsby
Male, Rat, Long Evans
Wild type
Andres Grosmark 2

Sessions

Sessions

Animal name

Date

Subsessions

Achilles_10252013
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Achilles October 25, 2013 Homecage_Sleep, LinearTrack_EndToEnd, Homecage_Sleep
Achilles_10252013_01, Achilles_10252013_02, Achilles_10252013_03
Buddy_06272013
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Buddy June 27, 2013 Homecage_Sleep, LinearTrack_EndToEnd, Homecage_Sleep
Buddy_06272013_01, Buddy_06272013_02, Buddy_06272013_03
Cicero_09172014
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Cicero September 17, 2014 Homecage_Sleep, LinearTrack_EndToEnd, Homecage_Sleep
Cicero_09172014_01, Cicero_09172014_02, Cicero_09172014_03
Cicero_09012014
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Cicero September 1, 2014 Homecage_Sleep, LinearTrack_EndToEnd, Homecage_Sleep
Cicero_09012014_01, Cicero_09012014_02, Cicero_09012014_03
Gatsby_08022013
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Gatsby August 2, 2014 Homecage_Sleep, LinearTrack_EndToEnd, Homecage_Sleep
Gatsby_08022013_01, Gatsby_08022013_02, Gatsby_08022013_03
Achilles_11012013
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Achilles November 1, 2013 Homecage_Sleep, CircularTrack_EndToEnd, Homecage_Sleep
Achilles_11012013_01, Achilles_11012013_02, Achilles_11012013_03
Cicero_09102014
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Cicero September 10, 2014 Homecage_Sleep, CircularTrack_EndToEnd, Homecage_Sleep
Cicero_09102014_01, Cicero_09102014_02, Cicero_09102014_03
Gatsby_08282013
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Gatsby August 28, 2014 Homecage_Sleep, CircularTrack_EndToEnd, Homecage_Sleep
Gatsby_08282013_01, Gatsby_08282013_02, Gatsby_08282013_03