Project: Layer-specific physiological features and interlaminar interactions in the primary visual cortex of the mouse

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Description

A complex relationship exists between mesoscopic local field potentials (LFP) and single neuron firing. Using laminar recordings from all layers in the primary visual cortex (V1) of the behaving mouse, we quantified this relationship. Depth profiles of unit power and sink-source distributions of LFP provided consistent depth landmarks across animals. Coherence of gamma oscillations (30-100 Hz) and spike-LFP coupling identified six physiological layers and sublayers. Firing rates, burstiness and other features of neurons displayed unique layer and brain state-dependence. The most prominent LFP pattern during waking was a 3–6 Hz rhythm with characteristic phase preference of spikes across layers, which we consider as an evolutionary precursor of the primate alpha oscillations. Monosynaptic connections among neurons were assessed by spike transmission probability. Spike transmission between principal cells and interneurons was stronger during waking compared to non-REM sleep, but stronger among deep layer excitatory neurons during non-REM. These results bridge mesoscopic LFP and single neuron interactions
with laminar structure in V1.

Animals

Animal name

Investigator

Sessions

Animal actions

YMV16
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV17
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV18
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV19
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV01
Male, Mouse, C57B1/6
Ai35		 Yuta Senzai 1

Surgeries
2017-08-11, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV02
Male, Mouse, C57B1/6
Ai35		 Yuta Senzai 1

Surgeries
2017-08-14, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV03
Male, Mouse, C57B1/6
Ai35		 Yuta Senzai 1

Surgeries
2017-08-16, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV04
Male, Mouse, C57B1/6
CaMKII-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-06, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV05
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-11, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV06
Male, Mouse, C57B1/6
VGAT-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-12, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV08
Male, Mouse, C57B1/6
VGAT-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV07
Male, Mouse, C57B1/6
CaMKII-Cre::Ai35		 Yuta Senzai 1

Surgeries
2017-09-13, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV09
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV10
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV11
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV15
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV14
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




YMV13
Male, Mouse, C57B1/6
PV-Cre::Ai32		 Yuta Senzai 1

Surgeries
2017-09-21, 9:00: 14:00. grams.


Probe implants
Silicon probe Cambridge Neurotech H3 (64 ch, 1 shanks, linear ) | VISp | (1.0,2.5,)




Sessions

Sessions

Animal name

Date

Subsessions

YMV12_171211, Tags: Light stimulation, Opto stimulation, Sorted units
Public session. Webshare, Globus		 YMV12 December 11, 2017 Homecage_Sleep
YMV12_171211
YMV19_180209, Sorted units
Public session. Webshare, Globus		 YMV19 February 9, 2018 Homecage_Sleep
YMV19_180209
YMV18_180208, Sorted units
Public session. Webshare, Globus		 YMV18 February 8, 2018 Homecage_Sleep
YMV18_180208
YMV17_180207, Sorted units
Public session. Webshare, Globus		 YMV17 February 7, 2018 Homecage_Sleep
YMV17_180207
YMV16_180206, Sorted units
Public session. Webshare, Globus		 YMV16 February 6, 2018 Homecage_Sleep
YMV16_180206
YMV15_180205, Sorted units
Public session. Webshare, Globus		 YMV15 February 5, 2018 Homecage_Sleep
YMV15_180205
YMV14_180128, Sorted units
Public session. Webshare, Globus		 YMV14 January 28, 2018 Homecage_Sleep
YMV14_180128
YMV13_180127, Sorted units
Public session. Webshare, Globus		 YMV13 January 27, 2018 Homecage_Sleep
YMV13_180127
YMV11_171208, Sorted units
Public session. Webshare, Globus		 YMV11 December 8, 2017 Homecage_Sleep
YMV11_171208
YMV10_171213, Sorted units
Public session. Webshare, Globus		 YMV10 December 13, 2017 Homecage_Sleep
YMV10_171213
YMV09_171204, Tags: Light stimulation, Opto stimulation, Sorted units
Public session. Webshare, Globus		 YMV09 December 4, 2017 Homecage_Sleep
YMV09_171204
YMV08_170922, Tags: Light stimulation, Opto stimulation, Sorted units
Public session. Webshare, Globus		 YMV08 September 22, 2017 Homecage_Sleep
YMV08_170922
YMV07_170914, Sorted units
Public session. Webshare, Globus		 YMV07 September 14, 2017 Homecage_Sleep
YMV07_170914
YMV06_170913, Tags: Light stimulation, Opto stimulation, Sorted units
Public session. Webshare, Globus		 YMV06 September 13, 2017 Homecage_Sleep
YMV06_170913
YMV05_170912, Tags: Light stimulation, Opto stimulation, Sorted units
Public session. Webshare, Globus		 YMV05 September 12, 2017 Homecage_Sleep
YMV05_170912
YMV04_170907, Sorted units
Public session. Webshare, Globus		 YMV04 September 7, 2017 Homecage_Sleep
YMV04_170907
YMV03_170818, Sorted units
Public session. Webshare, Globus		 YMV03 August 18, 2017 Homecage_Sleep
YMV03_170818
YMV02_170815, Sorted units
Public session. Webshare, Globus		 YMV02 August 15, 2017 Homecage_Sleep
YMV02_170815
YMV01_170818, Sorted units
Public session. Webshare, Globus		 YMV01 August 18, 2017 Homecage_Sleep
YMV01_170818