Project: CRCNS Hippocampus: hc-3

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Multiple single unit recordings from different rat hippocampal and entorhinal regions while the animals were performing multiple behavioral tasks. [about]

The data set contains recordings made from multiple hippocampal areas in Long-Evans rats, including: Cornu Ammonis: CA1 and CA3; dentate gyrus (DG), and entorhinal cortex: EC2, EC3, EC4, EC5.  The data was obtained during 442 recording sessions and includes responses of 7,737 neurons in eleven animals while they performed one of fourteen behaviors.  Total time for all experiments is 204.5 hours.   The raw (broadband) data was recorded at 20KHz, simultaneously from 31 to 127 channels.  The raw data was processed to extract the LFPs (Local Field Potentials) and detect spikes. Included in the data set are the following items:

  • Times and waveforms of detected potential spikes.
  • Results of spike sorting.
  • LFPs.
  • For many sessions, the coordinate and direction of the rats head and video files from which the positions were extracted.
  • Metadata tables giving properties of the neurons and characteristics of the recording sessions.

A fuller description of the data set is in crcns-hc3-data-description.pdf

Several publication based on some of the data are:

Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop.
Mizuseki K, Sirota A, Pastalkova E, Buzsáki G., Neuron. 2009 Oct 29;64(2):267-80.

Hippocampal network dynamics constrain the time lag between pyramidal cells across modified environments.
Diba K, Buzsáki G., J Neurosci. 2008 Dec 10;28(50):13448-56.

The following publication describes this data set:
Neurosharing: large-scale data sets (spike, LFP) recorded from the hippocampal-entorhinal system in behaving rats [version 2] Kenji Mizuseki, Kamran Diba, Eva Pastalkova, Jeff Teeters, Anton Sirota, György Buzsáki. F1000Research 2014, 3:98. doi: 10.12688/f1000research.3895.2