Cross-Species Neuromodulation from High-Intensity Transcranial Electrical Stimulation

News article about Antonio’s study in Scientific American by Simon Makin

Specific patterns of brain activity are thought to underlie specific processes or computations important for various mental faculties, such as memory. One such “brain signal” that has received a lot of attention recently is known as a “sharp wave ripple”—a short, wave-shaped burst of high-frequency oscillations.

Researchers originally identified ripples in the hippocampus, a region crucially involved in memory and navigation, as central to diverting recollections to long-term memory during sleep. Then a 2012 study by neuroscientists at the University of California, San Francisco, led by Loren Frank and Shantanu Jadhav, the latter now at Brandeis University, showed that the ripples also play a role in memory while awake. The researchers used electrical pulses to disrupt ripples in rodents’ brains, and showed that, by doing so,  performance in a memory task was reduced. However, nobody had manipulated ripples to enhance memory—until now, that is.

Read the full article here and see Antonio’s related study below.

Long-duration Hippocampal Sharp Wave Ripples Improve Memory Fernández-Ruiz A, Oliva A, Fermino de Oliveira E, Rocha-Almeida F, Tinlgey D, Buzsáki G.. Science, June 2019. [Link] [Supplemental]