English, McKenzie, et al. identify, validate, and quantify monosynaptic connections between pyramidal cells and interneurons, using the spike timing of pre- and postsynaptic neurons in vivo. Their large-scale method uncovers a backbone of connectivity rules in the hippocampus CA1 circuit.
Highlights
- Pyramidal cell-interneuron monosynaptic connections identified using spike timing
- Skewed distribution of connection probability and strength
- Short-term plasticity of connection strength is synapse specific
- Presynaptic cooperativity and postsynaptic timing impact spike transmission probability
